Optimasi formula effervescent berbasis nanoenkapsulat Eucalyptus citriodora

Kendri Wahyuningsih; Nausika Estetia Putri Jatmiko; Rohula Utami; Sri Yuliani

doi:10.21107/agrointek.v16i3.12879

Optimasi formula effervescent berbasis nanoenkapsulat Eucalyptus citriodora

Kendri Wahyuningsih, Nausika Estetia Putri Jatmiko, Rohula Utami, Sri Yuliani

Abstract

Eucalyptol (1,8-cineole) compound contained in eucalyptus oil has the potential to inhibit viral infection pathways, as an antimicrobial and as an immunoregulator. Therefore, the development of eucalyptus oil-based effervescent health drinks is urgently needed to relieve the symptoms of being infected a virus during this pandemic. However, the volatility of eucalyptus oil is quite high, so a nano-based encapsulation method is needed to slow release of these volatile compounds. This study aims to obtain the best formula for Eucalyptus citriodora oil-based effervescent granules with controlled release system in nanostructure. The experimental design used was the Taguchi method with 3 replications. The combination of level factors in the optimal formula obtained through the Taguchi loss function optimization method were effervescent materials factor-level 2, lactose/sucralose ratio factor-level 3 and nanoencapsulated/ascorbic acid ratio factor-level 2. The optimal formula was (1) effervescent materials factor: 24% sodium bicarbonate, 12% tartaric acid, 11% citric acid; (2) lactose/sucralose ratio factor: 46.2% / 0.2%; (3) nanoencapsulated/ascorbic acid ratio factor: 4.5% / 2%. The optimal product characteristics were water content of 5.52%, pH of 5.9, dissolving time of 106 seconds, carr's index of 23.56, hausner's ratio of 1.31, and total essential oil content of 0.014mL/4gram. This product can be used as a health drinks (throat lozenges) and immune booster.

Keywords

Immune booster; Health drinks; Eucalyptol; Taguchi

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References

Abdoun, S., T. I. Hassan, D. A. Gaber, and A. El- Sharekh. 2019. Antidepressant activity of A. hierochuntica L. effervescent granules using forced swimming test. Journal of Innovations in Pharmaceutical and Biological Sciences (JIPBS) 6:38–44.

Ansel, H. C. 2008. Pharmaceutical Dosage Form and Delivery System, terjemahan Farida Ibrahim, Pengantar Bentuk Sediaan Farmasi. UI Press, Depok.

Aprilia, A., N. I. Satria, A. D. Septyarini, and M. Maherawati. 2021. Review: Formulasi tablet effervescent berbahan dasar alami. Agrointek 15:1001–1009.

De Araújo-Filho, J. V., W. L. C. Ribeiro, W. P. P. André, G. S. Cavalcante, T. T. Rios, G. M. Schwinden, L. O. Da Rocha, I. T. F. Macedo, S. M. de Morais, C. M. L. Bevilaqua, and L. M. B. De Oliveira. 2019. Anthelmintic activity of Eucalyptus citriodora essential oil and its major component, citronellal, on sheep gastrointestinal nematodes. Revista Brasileira de Parasitologia Veterinaria 28:644–651.

Bilia, A. R., C. Guccione, B. Isacchi, C. Righeschi, F. Firenzuoli, and M. C. Bergonzi. 2014. Essential oils loaded in nanosystems: A developing strategy for a successful therapeutic approach. Evidence-Based Complementary and Alternative Medicine 651593. Hindawi Publishing Corporation:1-14.

Ciobanu, A., I. Mallard, D. Landy, G. Brabie, D. Nistor, and S. Fourmentin. 2013. Retention of aroma compounds from Mentha piperita essential oil by cyclodextrins and crosslinked cyclodextrin polymers. Food Chemistry 138:291–297.

Das, S., and A. Chaudhury. 2011, March. Recent advances in lipid nanoparticle formulations with solid matrix for oral drug delivery. AAPS PharmSciTech 12:62-76.

Deshmukh, K., and C. Kapadia. 2017. Comparative evaluation of Compritol® HD5 ATO with Sodium Stearyl Fumarate and PEG 6000 as amphiphilic, hydrodispersible pharmaceutical lubricants. J. Excipients and Food Chem 8:5–18.

Dwi Rusita, Y., R. Desty Rakhmayanti, and P. Kemenkes Surakarta. 2019. Universitas Muhammadiyah Semarang Seminar Nasional Publikasi Hasil-Hasil Penelitian dan Pengabdian Masyarakat Formulasi Sediaan Serbuk Effervescent Ekstrak Daun Kelor (Moringa oleifera L.).

Fardiaz, S. 1989. Praktek Mikrobiologi Pangan. Lembaga Sumberdaya Informasi. . IPB Press, Bogor.

Gabetti, E., B. Sgorbini, F. Stilo, C. Bicchi, P. Rubiolo, F. Chialva, S. E. Reichenbach, V. Bongiovanni, C. Cordero, and A. Cavallero. 2021. Chemical fingerprinting strategies based on comprehensive two-dimensional gas chromatography combined with gas chromatography-olfactometry to capture the unique signature of Piemonte peppermint essential oil (Mentha piperita var Italo-Mitcham). Journal of Chromatography A 1645:462101.

Gaitonde, V. N., S. R. Karnik, T. Achyutha, and B. Siddeswarappa. 2006. Multi-response optimization in drilling using Taguchi’s quality loss function. Indian Journal of Engineering & Materials Sciences 13:484-488.

Gupta, R., P. Sharma, A. Garg, A. Soni, A. Sahu, S. Rai, S. Rai, and A. Shukla. 2013. Formulation and Evaluation of Herbal Effervescent Granules Incorporated with Calliandra haematocephala Leaves Extract. Indo American Journal of Pharmaceutical Research 3.

Hsouna, A. Ben, N. Touj, I. Hammami, K. Dridi, A. S. Al-Ayed, and N. Hamdi. 2019. Chemical composition and in vivo efficacy of the essential oil of Mentha piperita L. In the suppression of crown gall disease on tomato plants. Journal of Oleo Science 68:419–426.

Hutagalung, F. S., K. H. Dewi, and B. Sidebang. 2019. Effects of Heating and Sugar on the Quality of Hard Candy Made of Syrup Kalamansi Sideproduct. Jurnal Agroindustri 8:97–104.

Jubahar, J., Y. Astuti, and D. N. Suharti. 2015. Penetapan kadar vitamin c dari buah cabe rawit (Capsicum frutescens L.) Dengan metode kromatografi cair kinerja tinggi (KCKT). Jurnal Farmasi Higea 7:208-2017.

Kailaku, S. I., J. Sumangat, 2012. Formulasi granul efervesen kaya antioksidan dari ekstrak daun gambir. J. Pascapanen 9:27-34.

Kusuma, H. R., T. Ingewati, N. Indraswati, and Martina. 2007. Pengaruh pasteurisasi terhadap kualitas jus jeruk pacitan. WIDYA TEKNIK 6:142–151.

Lestari, A. B. S., and M. Y. Trisusilawati. 2010. Pengaruh asam fumarat-natrium bikarbonat terhadap kualitas granul effervescent teh hijau secara granulasi kering. Majalah Farmasi Indonesia 21:218–224.

Madan, S. S., and K. L. Wasewar. 2017. Optimization for benzeneacetic acid removal from aqueous solution using CaO2 nanoparticles based on Taguchi method. Journal of Applied Research and Technology 15:332–339.

Madhavi, N., D. Kumar, S. Naman, M. Singh, P. Amol Singh, N. Bajwa, and A. Baldi. 2019. Formulation and Evaluation of Novel Herbal Formulations Incorporated with Amla Extract for Improved Stability. Journal of Drug Delivery & Therapeutics 9:212–221.

Maftuchah, P. I. Christine, and M. Jamaluddin. 2020. The Effectiveness of Tea Tree Oil and Eucalyptus Oil Aromaterapy for Toddlers with Common Cold. Jurnal Kebidanan 10:131–137.

Miskiyah, Widaningrum, and C. Winarti. 2011. Edible Coating Berbasis Pati Sagu dan Vitamin C untuk Meningkatkan Daya Simpan Paprika Merah (Capsicum annum var. Athena). J. Pascapanen 8:39–46.

Nurahmanto, D., M. Irine Prabandari, and B. Triatmoko. 2017. Optimasi formula granul effervescent kombinasi ekstrak kelopak bunga Hibiscus sabdariffa L. Dan ekstrak daun Guazuma ulmifolia Lam. Pharmacy 14:220-235.

Pain, G. 2007. Eucalyptus oil applications and markets. Perth.

Panyod, S., C. T. Ho, and L. Y. Sheen. 2020, July. Dietary therapy and herbal medicine for COVID-19 prevention: A review and perspective. National Taiwan University.

Paredes, A., C. M. Asensio, J. Llabot, D. Allemandi, and S.D. Palma. 2016. Nanoencapsulation in the food industry: manufacture, applications and characterization. Journal of Food Bioengineering and Nanoprocessing 1: 56-79..

Saifullah, M., Y. A. Yusof, N. L. Chin, and M. G. Aziz. 2016. Physicochemical and flow properties of fruit powder and their effect on the dissolution of fast dissolving fruit powder tablets. Powder Technology 301:396–404.

Sandrasari, D. A., and A. Zaenal. 2011. Determination of the concentrations of sodium bicarbonate and citric acid in carbonated grape drink (effervescent) production. J. Tek. Ind. Pert. 21:113–117.

Sanjiwani, N. M. S., D. A. I. Paramitha, A. A. C. Wibawa, I. M. D. Ariawan, N. W. T. Dewi, N. M. D. Wahyuni, and I. W. Sudiarsa. 2020. Analysis and characterization of lavender and peppermint essential oils with mass gas-spectroscopic chromatography (GC-MS). Jurnal Edukasi matematika dan Sains 9:1–10.

Shao, J., Z. Yin, Y. Wang, Y. Yang, Q. Tang, M. Zhang, J. Jiao, C. Liu, M. Yang, L. Zhen, A. Hassouna, W. L. White, and J. Lu. 2020. Effects of Different Doses of Eucalyptus Oil from Eucalyptus globulus Labill on Respiratory Tract Immunity and Immune Function in Healthy Rats. Frontiers in Pharmacology 11:1–8.

Sharma, A. D., and I. Kaur. 2020. Eucalyptol (1,8 cineole) from eucalyptus essential oil a potential inhibitor of COVID 19 corona virus infection by Molecular docking studies. Preprints 2020030455:1–8.

Shittu, T. A., and M. O. Lawal. 2007. Factors affecting instant properties of powdered cocoa beverages. Food Chemistry 100:91–98.

Siswanto Syamsul, E., S. Akademi Farmasi Samarinda, J. AWahab Sjahranie No, and E. Kalimantan. 2014. Formulation of effervescent powder of water extract of bawang tiwai (Eleuterine palmifolia) as a healthy drink. Traditional Medicine Journal 19:113-117.

Tarwendah, I. P., 2017. Comparative Study of Sensory Attributes and Brand Awareness in Food Product : A Review. Jurnal Pangan dan Agroindustri 5: 66-73.

Tudela, J. A., J. C. Espín, and M. I. Gil. 2002. Vitamin C retention in fresh-cut potatoes. Postharvest Biology and Technology 26:75-84..

Violalita, F., and B. Rini. 2015. The Effect Acid Addition on Characteristic Effervescent Tablet of Tamarillo. International Journal on Advanced Science Engineering Information Technology 5:230–233.

Yang, F. L., X. G. Li, F. Zhu, and C. L. Lei. 2009. Structural characterization of nanoparticles loaded with garlic essential oil and their insecticidal activity against Tribolium castaneum (Herbst) (Coleoptera: Tenebrionidae). Journal of Agricultural and Food Chemistry 57:10156–10162.