Mephenamic Acid Treatment Toward Follicles Development and Progesterone

S Aminah, D K Prasetyanti, D Lutfiasari, M E Fitriasnani

Abstract


Mefenamat acid is anti-inflammation non steroid which can hamper prostaglandin synthesis in the body tissue by hampering siklooxigen enzyme. The purpose of this research is to find out the influence of mefenamat acid toward the follicles development and progesterone level. This research his experimental laboratory method. The subject of the research divided into five groups randomly selected and  have been homogenized. One group as control group and others as experimental  group with various dos age of Mephenamic Acidtreatment. The data is analyzed to discover average difference the quantity off ollicles and blood progesterone level using one way Anova test. The results of this research is confirmed the significantly difference of  Grafian follicles, yello wish corpus luteumand proges terone level as the influence of Mephenamic Acidin 0.5 mg/kg, 1mg/kg, 1.5  mg/kg, and 2  mg/kg; while there was no significantly difference intertiary follict les development. The decrease of corpus luteumis caused by mefenamat acid activity to hamper the prostaglandin synthesis in the body tissue by hampering siklooxigen enzyme. Prostaglandincan make follicles swelling and cause follicles fracture and make ovulation. The granulosis cell will makecorpus luteumwhich secreted progesterone hormone. Mephenamic Acid was proven to  avoid ovulation that blocked the formation  of yello wish  corpus luteum result ingin the decreased  of blood progesterone level.

Full Text:

PDF

References


Darrell Hulisz, “Nonsteroidal Anti-inflammatory Drugs and Infertility.” Medscape, 2015.

J. Fricová, Nonopioid analgesics, Fourth Edi., vol. 157, no. 2. Elsevier, 2018.

W. S. Weintraub, “Safety of non-steroidal anti-inflammatory drugs,” Eur. Heart J., vol. 38, no. 44, pp. 3293–3295, 2017.

E. Zaini, L. Fitriani, R. Y. Sari, H. Rosaini, A. Horikawa, and H. Uekusa, “Multicomponent Crystal of Mefenamic Acid and N-Methyl-D-Glucamine: Crystal Structures and Dissolution Study,” J. Pharm. Sci., vol. 108, no. 7, pp. 2341–2348, 2019.

A. Al-Shidhani, N. Al-Rawahi, A. Al-Rawahi, and S. Murthi P, “Non-steroidal anti-inflammatory drugs (NSAIDs) use in primary health care centers in A’Seeb, Muscat: A clinical audit,” Oman Med. J., vol. 30, no. 5, pp. 366–371, 2015.

A. Arfè et al., “Non-steroidal anti-inflammatory drugs and risk of heart failure in four European countries: nested case-control study,” BMJ, vol. 354, p. i4857, 2016.

M. Antonio, N. L. Calvo, and R. M. Maggio, “Chemometric study of the excipients’ influence on polymorphic-behavior. Mefenamic acid as case of study,” J. Pharm. Biomed. Anal., 2019.

I. Talimkhani, M. R. Jamalpour, H. Babaei, and J. Faradmal, “Comparison of Intra-Socket Bupivacaine Administration Versus Oral Mefenamic Acid Capsule for Postoperative Pain Management Following Removal of Impacted Mandibular Third Molars,” J. Oral Maxillofac. Surg., vol. 77, no. 7, pp. 1365–1370, 2019.

K. Abadian, Z. Keshavarz, F. Mojab, H. Alavi Majd, and N. M. Abbasi, “Comparison the effect of mefenamic acid and Teucrium polium on the severity and systemic symptoms of dysmenorrhea,” Complement. Ther. Clin. Pract., vol. 22, pp. 12–15, 2016.

H. M, A.-F. Ahmad .M ,Al-Zohyri, and M. Q.Al-Atrakji, “Pharmacological effects of low doses of some commonly used NSAIDs on ovulation and corpus luteum in mature female mice *Acellular and Hormanal comparative study *,” IOSR J. Pharm. Biol. Sci., vol. 9, no. 5, pp. 38– 44, 2014.

Harison, “NSAIDs Dramatically Reduce Ovulation With Consistent Use.” Medscape, 2015.

S. A. Ryan, “The Treatment of Dysmenorrhea,” Pediatr. Clin. North Am., vol. 64, no. 2, pp. 331–342, 2017.

M. A. Friederich, Dysmenorrhea, Fourth Edi. Elsevier Inc., 2017.

H. Malm and C. Borisch, Analgesics, non-steroidal anti-inflammatory drugs (NSAIDs), muscle relaxants, and antigout medications, Third Edit., no. Roberts 1984. Elsevier B.V., 2014.

Y. Li et al., “This is a postprint of an article published in Dror , N ., Alter-Koltunoff , M ., Azriel , A ., Amariglio , N ., Jacob-Hirsch , J ., Zeligson , S ., Morgenstern , A ., Tamura , T ., Hauser , H ., Rechavi , G ., Ozato , K ., Levi , B . -Z . Identification ,” Int. Urol. Nephrol., vol. 44, no. Paper 18569, pp. 338–346, 2014.

T. R. Aritonang et al., “The Role of FSH, LH, Estradiol and Progesterone Hormone on Estrus Cycle of Female Rats,” Int. J. Sci. Basic Appl. Res., vol. 35, no. 1, pp. 92–100, 2017.

A. zohyri Salman S, Sherif B, “Effects of Some Non Steroidal Anti-Inflammatory Drugs on Ovulation in Women with Mild Musculoskeletal Pain.” BMJ JournalVolume 74, Issue Suppl 2, 2015.


Refbacks

  • There are currently no refbacks.